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Investigators at the Stanford University School of Medicine and the Buck Institute for Research on Aging have built an inflammatory-aging clock that's more accurate than the number of candles on your birthday cake in predicting how strong your immune system is, how soon you'll become frail or whether you have unseen cardiovascular problems that could become clinical headaches a few years down the road. In the process, the scientists fingered a bloodborne substance whose abundance may accelerate cardiovascular aging. The story of the clock's creation will be published today (July 12, 2021) in Nature Aging. "Every year, the calendar tells us we're a year older," said David Furman, PhD, the study's senior author. "But not all humans age biologically at the same rate. You see this in the clinic -- some older people are extremely disease-prone, while others are the picture of health."

An inflammatory ageing clock can predict how strong your immune system is and when you'll become frail by analysing your blood, according to its developers. The AI-driven device can diagnose life-threatening illness years before any symptoms begin to develop, allow for early treatment and improved recovery. The system can also determine frailty levels in old age seven years in advance, say researchers from the Buck Institute for Research on Aging in Novato, California. The US team analysed blood samples from 1,001 individuals aged eight to 96 years as part of a project called '1000 Immunomes', to create a prediction score. It's even more accurate than the number of candles on your birthday cake, say scientists from Stanford University School of Medicine, who also worked on its development, as it is based on blood-borne proteins that drive chronic inflammation.

The new collaboration is an indication of research into aging biomarkers together with the interventions discovered over the past five years is advancing. The collaboration is through the startup Napa Therapeutics, Ltd. Napa is to develop drugs against a novel aging-related target, as Business Insider reports. In terms of what each company will offer, the Buck Institute is one of the primary research centers focused on research into aging and the elimination of age-related disease. Insilico Medicine is an artificial intelligence pioneer, which is looking at on a range of factors associated with aging.

Sensyne Health, a London-based healthcare artificial intelligence (AI) company founded by biotech entrepreneur Paul Drayson, recently launched an initial public offering (IPO) on the London AIM market. Drayson's plan is to raise $78 million. It's just one of many companies that are exploiting advances in computing, data science and AI to help identify and develop potential new drugs. Drayson was formerly the UK's Minister of Science in the Department for Business, Innovation and Skills until May 2010, and before that, Minister of State for Strategic Defence Acquisition Reform at the Ministry of Defence. Drayson co-founded vaccine maker PowderJect Pharmaceuticals in 1993 and sold it in 2003 to Chiron for 524 million pounds.

Recent advances in modern artificial intelligence demonstrated promising results in both biomarker development and drug discovery and the leading academic and research institutions are expanding their AI groups. The Buck Institute is the leading research institution with massive amounts of biological data coming from high-throughput experiments and with the unique multidisciplinary expertise in aging research. Alex Zhavoronkov works on the intersection of the next-generation of artificial intelligence and aging research and will help support the AI efforts at the Buck. "We are incredibly excited about the potential of AI to accelerate aging research," said Dr. Eric Verdin, President and CEO of the Buck Institute. "The Buck has been at the forefront of asking the most important questions in the field. Now, with the latest in bioinformatics and artificial intelligence, and with the involvement of world-class experts like Dr. Zhavoronkov, we will finally have the tools to answer them. Fully utilizing these powerful technologies, we will dramatically increase our understanding of how aging works, and what we can do about it."